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Brian Randolph Greene (born February 9, 1963) is an American physicist known for his research on string theory. He is a professor of physics and mathematics at Columbia University and the chairman of the World Science Festival, which he co-founded in 2008. Greene has worked on mirror symmetry, relating two different Calabi–Yau manifolds (concretely relating the conifold to one of its orbifolds). He also described the flop transition, a mild form of topology change, showing that topology in string theory can change at the conifold point.

Greene has become known to a wider audience through his books for the general public, The Elegant Universe, Icarus at the Edge of Time, The Fabric of the Cosmos, The Hidden Reality, and related PBS television specials. He also appeared on The Big Bang Theory episode "The Herb Garden Germination", as well as the films Frequency and The Last Mimzy. He is currently a member of the board of sponsors of the Bulletin of the Atomic Scientists.